Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women
نویسندگان
چکیده
منابع مشابه
Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women
OBJECTIVE Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and the interactions between IL6R variants and CRP in relation to diabetes risk....
متن کاملInterleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women.
OBJECTIVE To examine the associations between common variations in the IL6R gene and circulating interleukin (IL)-6 levels and diabetes risk. RESEARCH DESIGN AND METHODS We determined 10 linkage disequilibrium (LD)-tagging single nucleotide polymorphisms (SNPs) (SNP1 to SNP10) for the IL6R gene in a nested case-control study of 672 diabetic and 1,058 healthy European Caucasian women (IL-6 lev...
متن کاملComparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women.
Although markers of systemic inflammation may have a role in the development of hypertension, supportive clinical data remain limited. We, therefore, examined interleukin (IL)-6 and C-reactive protein (CRP) in a nested case-control study of 400 women developing hypertension and an equal number of age-matched normotensive control subjects during 10 years of follow-up as part of the Women's Healt...
متن کاملInterrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women.
OBJECTIVE Interleukin-6 (IL-6) and C-reactive protein (CRP) are markers of systemic vascular inflammation that herald atherothrombosis and may have important interrelationships with traditional cardiovascular risk factors. METHODS AND RESULTS We conducted a cross-sectional analysis among 340 apparently healthy women enrolled in the Women's Health Study. In unadjusted analyses, higher levels o...
متن کاملC-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus.
CONTEXT Inflammation is hypothesized to play a role in development of type 2 diabetes mellitus (DM); however, clinical data addressing this issue are limited. OBJECTIVE To determine whether elevated levels of the inflammatory markers interleukin 6 (IL-6) and C-reactive protein (CRP) are associated with development of type 2 DM in healthy middle-aged women. DESIGN Prospective, nested case-co...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2008
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-0968